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Item specifics

Condition:
New with tags: A brand-new, unused, and unworn item (including handmade items) in the original ...
Colour:
Black
Size:
12 mm
Product Type:
Straps
MPN:
Does Not Apply
Brand:
Seiko
EAN:
Does not apply



Seiko Lizard Grain Leather Strap Watch 12 MM Inc Bars

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    Many DUBs regulate mitophagy in a positive or negative manner. In healthy mitochondria, PINK1 is constitutively imported into the mitochondria for processing and release into the cytosolic area, followed by rapid degradation. However, when the mitochondrial membrane potential (ΔΨm) dissipates, PINK1 is stabilized on the OMM and forms a large complex on the OMM surface where it recruits parkin to the damaged mitochondria. The accumulated PINK1 phosphorylates parkin and attaches ubiquitin chains to several mitochondrial substrates, such as translocase of the outer membrane 20 (Tom20), voltage-dependent anion-selective channel 1 (VDAC1), and mitofusin-2 (MFN2). Such ubiquitinated proteins may act as adaptors for sequestosome-1 (SQSTM1/p62) and promote the translocation of defective mitochondria to the autophagosome followed by sequential steps of mitophagy. Multiple DUBs regulate mitophagy in a positive/negative manner. For example, USP8 and USP13 promote mitophagy by directly detaching ubiquitin from parkin, whereas USP15, USP30, USP33, and USP35 inhibit parkin-mediated ubiquitination of OMM proteins. Accordingly, these DUBs promote or suppress mitophagy during the removal of ubiquitin from the parkin. USP14 negatively regulates proteasome activity, and also acts as a negative regulator of mitophagy.

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BMB Reports 2021; 54(12): 581~631
Invited Mini Reviews
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BMB Reports 2021; 54(12): 581-591  2022 Heartland Prowler, White with 0 available now!
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Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas: a systematic analysis and review
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BMB Reports 2021; 54(12): 601-607  https://doi.org/10.5483/BMBRep.2021.54.12.165
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December 2021
Volume 54
Issue 12

2020 SCI Impact Factor 4.778

BIOCHEMISTRY & MOLECULAR BIOLOGY 98/298

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